Comparative analysis of international prognostic index for chronic lymphocytic leukemia, progression-risk score, and MD Anderson Cancer Center 2011 score - a single center experience

Introduction/Objective. Prognostication of chronic lymphocytic leukemia (CLL) has been substantially improved in recent times. Among several prognostic models (PMs) focused on the prediction time to first treatment (TTFT), progression-risk score (PRS), and MD Anderson Cancer Center 2011 (MDACC 2011) are most relevant, while CLL-International Prognostic Index (CLL-IPI), although originally developed predict overall survival (OS), is also being used estimate TTFT. The aim this study was investigate CLL-IPI, PRS, MDACC values regarding TTFT OS. Methods. analyzed cohort included 57 unselected Serbian CLL patients from a single institution, with basic characteristics reflecting more aggressive disease than general de novo population. eligible were assigned investigated PMs, OS analyses performed. Results. Patients higher risk scores according underwent significantly earlier lower (p = 0.002, p 0.019, < 0.001, respectively). In multivariate analysis, CLL-IPI retained their significance 0.001 0.018, respectively), PRS did not. only significant predictor both at univariate 0.005) 0.013) levels. Conclusion. particularly able even cohorts advanced-disease patients, for OS, applicable among three PMs. These results imply that PMs should be diverse populations, as it real-life setting.